1-Phenylpiperazine → ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

Participants

Reaction Steps

1-Phenylpiperazine (10 g, 62 mmol) was added to a solution of ethyl isothiocyanatoformate (8.1 g, 62 mmol) in acetone (30 mL) and the mixture was refluxed under heating for 1 h. The reaction mixture was concentrated and the crude crystals were recrystallized from ethyl acetate to give the title compound (13 g, yield 73%).

Provenance & Evidence