1-Phenylpiperazine → ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

HRID 1062647Notes

Reaction equation

HRID 1062647 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:14]=[S:15]>CC(C)=O>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:14]([NH:13][C:16](=[O:17])[O:18][CH2:19][CH3:20])=[S:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 85320Ethyl isothiocyanatoformate

Product 1

HCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATEYield 73%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1-Phenylpiperazine (10 g, 62 mmol) was added to a solution of ethyl isothiocyanatoformate (8.1 g, 62 mmol) in acetone (30 mL) and the mixture was refluxed under heating for 1 h. The reaction mixture was concentrated and the crude crystals were recrystallized from ethyl acetate to give the title compound (13 g, yield 73%).

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 1 h
  3. concentrationThe reaction mixture was concentrated
  4. customthe crude crystals were recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-8a23039afdd64352a11e024d78fc44aa
Source dataset
uspto-grants-2005_11
Patent number
US06962933B1

Reaction notes

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