Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

HRID 1062648Notes

Reaction equation

HRID 1062648 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15]C(=O)OCC)=[S:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[S:14])[NH2:15])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

Product 1

HCID 20517984-PHENYL-1-PIPERAZINECARBOTHIOAMIDEYield 63%

Conditions

Temperature
80 °C

Procedure

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL) and the mixture was stirred at 80° C. for 2 h. The reaction mixture was made basic with 8N aqueous sodium hydroxide solution and the crystals were collected by filtration. The crystals were washed with water and dried to give the title compound (6.1 g, yield 63%).

Workup

  1. filtrationthe crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried

Sources & evidence

ORD record
ord-39c6e7e35fd646cc9aeb751855e24757
Source dataset
uspto-grants-2005_11
Patent number
US06962933B1

Reaction notes

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