反应详情

温度

120 °C

A mixture of 4-trifluoromethyl phenol (2 g), K2CO3 (2.04 g) and epichlorohydrin (10 mL) was stirred at 120° C. for 4 hrs. After completion of reaction, the solid was filtered, filtrate was Diluted with water (50 mL) and extracted with ethylacetate (3×25 mL). Organic layer was washed with Distilled water (3×100 mL) and concentrated to an oil, which was purified on silica gel column using hexane:ethylacetate (9:1) as eluant, to given required compound 2.42 g (90%) yield.

1. customAfter completion of reaction
2. filtrationthe solid was filtered
3. additionfiltrate was Diluted with water (50 mL)
4. extractionextracted with ethylacetate (3×25 mL)
5. washOrganic layer was washed with Distilled water (3×100 mL)
6. concentrationconcentrated to an oil, which
7. customwas purified on silica gel column
8. customyield