反应详情

To 4-(tert-butyl)-N-[3-{2-[(5-formyl-2-pyrimidinyl)oxy]ethoxy}-1-methyl-4-(4-methylphenyl)-1H-pyrazol-5-yl]benzenesulfonamide (Example 38) (25 mg) in ethanol (0.5 ml) at room temperature was added sodium borohydride (2 mg) the mixture was stirred for 1 hr. The reaction was treated with ammonium chloride (aq. sat. 5 ml) and extracted with diethyl ether (1×5 ml, 1×2 ml). The organic fraction was dried over magnesium sulfate, filtered and concentrated under reduced pressure to yield the title compound as a white solid (20 mg).

1. extractionextracted with diethyl ether (1×5 ml, 1×2 ml)
2. dry with materialThe organic fraction was dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure