Ammonium Chloride → HCID 22281969, compound

HRID 1062804Notes

Reaction equation

HRID 1062804 reaction equation
C([O:4][CH2:5][CH2:6][O:7][C:8]1[C:12]([C:13]2[CH:21]=[CH:20][C:16]3[O:17][CH2:18][O:19][C:15]=3[CH:14]=2)=[C:11]([NH2:22])[N:10]([CH3:23])[N:9]=1)(=O)C.[Na].[Cl-].[NH4+]>C(O)C.O>[NH2:22][C:11]1[N:10]([CH3:23])[N:9]=[C:8]([O:7][CH2:6][CH2:5][OH:4])[C:12]=1[C:13]1[CH:21]=[CH:20][C:16]2[O:17][CH2:18][O:19][C:15]=2[CH:14]=1

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 23400310HCID 23400310, compound

Product 1

HCID 22281969HCID 22281969, compoundYield 97.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}ethyl acetate (100 mg) (Preparation 33) in ethanol (6 ml) at room temperature, was added sodium hydroxyde (100 mg). After one hour, the reaction was diluted with water (5 ml) and an aqueous saturated solution of ammonium chloride (10 ml). The mixture was extracted with ethyl acetate (3×6 ml). The organic fraction was dried over sodium sulfate and concentrated under reduced pressure to yield the title compound as a white solid (85 mg).

Workup

  1. extractionThe mixture was extracted with ethyl acetate (3×6 ml)
  2. dry with materialThe organic fraction was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-4810610c3e7a47a48a5fc640b37872ea
Source dataset
uspto-grants-2005_11
Patent number
US06962923B2

Reaction notes

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