反应详情

温度

80 °C

Using a method similar to Example 15 a), 6.75 g (0.03 mol) of (2), 8.5 g (0.033 mol) of 3,5-bis(trifluoromethyl)phenylboronic acid and 7.0 g (0.066 mol) of sodium carbonate were placed in 120 ml of dimethoxyethane and 36 ml of water in the reaction vessel, the mixture was degassed a number of times and saturated with argon. 120 mg (0.5 mmol) of palladium acetate and 282 mg (1.1 mmol) of TPP were added and the reaction mixture was stirred for 2 hours at 80° C. After addition of 150 ml of water, the mixture was extracted 3 times with 150 ml each time of diethyl ether, the combined ether phases were washed 3 times with 150 ml each time of water and dried over magnesium sulfate. Removal of the solvent gave 9.93 g of (18) as an oil.

1. custom36 ml of water in the reaction vessel, the mixture was degassed a number of times
2. extractionthe mixture was extracted 3 times with 150 ml each time of diethyl ether
3. washthe combined ether phases were washed 3 times with 150 ml each time of water
4. dry with materialdried over magnesium sulfate
5. customRemoval of the solvent