反应详情

2-Amino-4-chlorobenzothiazol (92 mg, 0.50 mmol) is dissolved in dichloromethane (10 ml) and treated with pyridine (0.060 ml, 0.75 mmol) and 5-methyl-thiophene-2-carbonyl chloride (97 mg, 0.60 mmol). The reaction mixture is stirred at ambient temperature for 18 h and then evaporated to dryness. The residue is redissolved in ethyl acetate and water, the phases are separated and the organic layer extracted with brine. After dryin with sodium silfate, the solvent is removed in vacuo Flash chromatography on silica (eluent ethyl acetate/cyclohexane 1:4 affords the product as white solid.(88 mg, 57%). MS: m/e=308 (M+).

1. customevaporated to dryness
2. dissolutionThe residue is redissolved in ethyl acetate
3. customwater, the phases are separated
4. extractionthe organic layer extracted with brine
5. customthe solvent is removed in vacuo Flash chromatography on silica (eluent ethyl acetate/cyclohexane 1:4