Oxalyl chloride → HCID 21906247, compound

HRID 1063129Notes

Reaction equation

HRID 1063129 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(Cl)(=O)C([Cl:20])=O>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([Cl:20])=[O:16])[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

Product 1

HCID 21906247HCID 21906247, compound

Procedure

1-Boc-piperidine-4-carboxylic acid (4.4 g, 19.2 mmol) in oxalyl chloride (50 mL) was heated at reflux for 3 h and then concentrated and dried in vacuo to give the acid chloride, 4-chlorocarbonyl-piperidine-1-carboxylic acid tert-butyl ester.

Workup

  1. temperatureat reflux for 3 h
  2. concentrationconcentrated
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5221828bb8a54b578b8bd23339753922
Source dataset
uspto-grants-2005_11
Patent number
US06964956B2

Reaction notes

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