5-Amino-2-methylindole → [7-(2-Methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-morpholin-4-yl-methanone

HRID 1063169Notes

Reaction equation

HRID 1063169 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[O:23])[S:21][C:14]=12>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:13]1[CH:18]=[CH:17][N:16]=[C:15]3[CH:19]=[C:20]([C:22]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[O:23])[S:21][C:14]=13)=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 222786227-Chloro-thieno[3,2-b]pyridin-2-yl-morpholin-4-yl-methanone

Product 1

HCID 22278655[7-(2-Methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-morpholin-4-yl-methanone

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridin-2-yl-morpholin-4-yl-methanone by a procedure analogous to Example 1C. MS: 393 (MH+), HPLC Rf: 3.90 min.; HPLC purity 96%.

Sources & evidence

ORD record
ord-033588b956e7473ba3b597c80336148a
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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