5-Amino-2-methylindole → 7-(2-Methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carbonitrile

HRID 1063171Notes

Reaction equation

HRID 1063171 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]#[N:23])[S:21][C:14]=12>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:13]1[CH:18]=[CH:17][N:16]=[C:15]3[CH:19]=[C:20]([C:22]#[N:23])[S:21][C:14]=13)=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 222786367-Chlorothieno[3,2-B]pyridine-2-carbonitrile

Product 1

HCID 222786767-(2-Methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carbonitrile

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carbonitrile by a procedure analogous to Example 1C. MS: 305 (MH+), HPLC Rf: 4.86 min.; HPLC purity: 85%.

Sources & evidence

ORD record
ord-ea492e3343604397b8c24af2ed92cbf4
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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