Hydrochloric Acid → HCID 22278629, compound

HRID 1063185Notes

Reaction equation

HRID 1063185 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3[NH:25][C:26]3[CH:27]=[C:28]4[C:32](=[CH:33][CH:34]=3)[NH:31][C:30]([CH3:35])=[CH:29]4)[CH:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>>[CH3:35][C:30]1[NH:31][C:32]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH:25][C:22]1[CH:21]=[CH:20][N:19]=[C:18]3[CH:17]=[C:16]([C:14]([N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[O:15])[S:24][C:23]=13)=[CH:34][CH:33]=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69735816HCID 69735816, compound

Product 1

HCID 22278629HCID 22278629, compound

Procedure

The title compound was prepared by treating 4-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester with HCl gas as described in Example 64B. MS: 392 (MH+); HPLC Rf: 3.51 min.; HPLC purity: 93%.

Sources & evidence

ORD record
ord-2fc5f4af568b4e51acf2db7773ad1df6
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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