Iodoethane → HCID 23401163, compound

HRID 1063202Notes

Reaction equation

HRID 1063202 reaction equation
I[CH2:2][CH3:3].[OH:4][C@@H:5]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[S:20][C:19]3[C:14](=[N:15][CH:16]=[CH:17][C:18]=3[Cl:21])[CH:13]=2)=[O:11])[CH2:6]1>>[Cl:21][C:18]1[CH:17]=[CH:16][N:15]=[C:14]2[CH:13]=[C:12]([C:10]([N:7]3[CH2:8][CH2:9][C@@H:5]([O:4][CH2:2][CH3:3])[CH2:6]3)=[O:11])[S:20][C:19]=12

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 207677587-chloro-2-[(R)-3-hydroxypyrrolidine-1-carbonyl]thieno[3,2-b]pyridine

Product 1

HCID 23401163HCID 23401163, compound

Procedure

The title compound was prepared from iodoethane and (3R)-(3-hydroxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone by a procedure analogous to Example 67B. MS: 311.2/313.2 (MH+); HPLC Rf: 4.697 min.; HPLC purity: 98%.

Sources & evidence

ORD record
ord-e71261a87b3f4cb499d460f386796b04
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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