Bromomethylcyclopropane → HCID 69736337, compound

HRID 1063203Notes

Reaction equation

HRID 1063203 reaction equation
Br[CH2:2][CH:3]1[CH2:5][CH2:4]1.[OH:6][C@@H:7]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[Cl:23])[CH:15]=2)=[O:13])[CH2:8]1>>[Cl:23][C:20]1[CH:19]=[CH:18][N:17]=[C:16]2[CH:15]=[C:14]([C:12]([N:9]3[CH2:10][CH2:11][C@@H:7]([O:6][CH2:2][CH:3]4[CH2:5][CH2:4]4)[CH2:8]3)=[O:13])[S:22][C:21]=12

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 207677587-chloro-2-[(R)-3-hydroxypyrrolidine-1-carbonyl]thieno[3,2-b]pyridine

Product 1

HCID 69736337HCID 69736337, compound

Procedure

The title compound was prepared from bromomethyl-cyclopropane and (3R)-(3-hydroxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone by a procedure analogous to Example 67B. MS: 337.2/339.2 (MH+); HPLC Rf: 5.232 min.; HPLC purity 85%.

Sources & evidence

ORD record
ord-7792bc92f5b5424cb3e440de0729e4a7
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

Loading…