5-Amino-2-methylindole → (6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-[7-(2-methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone

HRID 1063217Notes

Reaction equation

HRID 1063217 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:18][CH:17]4[CH:15]([CH:16]4[N:19](C)C)[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH2:32])=[CH:27][CH:26]=2>>[NH2:19][CH:16]1[CH:17]2[CH:15]1[CH2:14][N:13]([C:11]([C:9]1[S:10][C:3]3[C:4](=[N:5][CH:6]=[CH:7][C:2]=3[NH:32][C:28]3[CH:29]=[C:30]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23]([CH3:22])=[CH:31]4)[CH:8]=1)=[O:12])[CH2:18]2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 22278613(7-Chloro-thieno[3,2-b]pyridin-2-yl)-(6-dimethylamino-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone

Product 1

HCID 10272524(6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-[7-(2-methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone

Procedure

The title compound was prepared from (7-chloro-thieno[3,2-b]pyridin-2-yl)-(6-dimethylamino-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to example 1C. MS: 432.2 (MH+); HPLC Rf: 4.346 min.; HPLC purity: 99%.

Sources & evidence

ORD record
ord-68e6c3c3cb23473198c4a37fd66ac215
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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