HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylindole → (6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-[7-(2-methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylindole | HCID 2733992 | — |
| Reactant | (7-Chloro-thieno[3,2-b]pyridin-2-yl)-(6-dimethylamino-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone | HCID 22278613 | — |
| Product | (6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-[7-(2-methyl-1h-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone | HCID 10272524 | — |
Reaction Steps
The title compound was prepared from (7-chloro-thieno[3,2-b]pyridin-2-yl)-(6-dimethylamino-3-aza-bicyclo[3.1.0]hex-3-yl)-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to example 1C. MS: 432.2 (MH+); HPLC Rf: 4.346 min.; HPLC purity: 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964961B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-68e6c3c3cb23473198c4a37fd66ac215 |
| Source note | uspto-grants-2005_11 |