HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-4-(pyrrolidin-2-ylmethyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 69736315 | HCID 69736315 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-4-(pyrrolidin-2-ylmethyl)morpholine | HCID 7141612 | 119.9% |
Reaction Steps
HCl (g) was introduced into a solution of (S)-2-morpholin-4-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (400 mg, 1.47 mmol) in MeOH. After 5 min., the reaction solution was concentrated under reduced pressure to give a white solid (300 mg, 99%). MS: 170.9 (MH+); HPLC Rf: n.d.; HPLC purity: n.d.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964961B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-e83fdfc8d48d44069425d5f57c394ac0 |
| Source note | uspto-grants-2005_11 |