Hydrochloric Acid → (S)-4-(pyrrolidin-2-ylmethyl)morpholine

HRID 1063219Notes

Reaction equation

HRID 1063219 reaction equation
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:14][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=O)(C)(C)C>CO>[NH:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:14][N:15]1[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69736315HCID 69736315, compound

Product 1

HCID 7141612(S)-4-(pyrrolidin-2-ylmethyl)morpholineYield 119.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl (g) was introduced into a solution of (S)-2-morpholin-4-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (400 mg, 1.47 mmol) in MeOH. After 5 min., the reaction solution was concentrated under reduced pressure to give a white solid (300 mg, 99%). MS: 170.9 (MH+); HPLC Rf: n.d.; HPLC purity: n.d.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e83fdfc8d48d44069425d5f57c394ac0
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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