Hydrochloric Acid → HCID 22278634, compound

Participants

Reaction Steps

HCl (gas) was bubbled through a solution of 4-(7-chloro-thieno[3,2-b]pyridine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (270 mg, 0.71 mmol) in MeOH (5 mL). After 15 min, TLC showed the reaction to be complete. The resulting HCl salt was obtained as a yellow oil (199 mg, 99%) after the solvent was removed under pressure. The title compound was prepared from the resulting HCl salt and acetyl chloride by a procedure analogous to Example 70A. MS: 325 (MH+); HPLC Rf: 3.62; HPLC purity: 95%.

Provenance & Evidence