Hydrochloric Acid → HCID 22278634, compound

HRID 1063228Notes

Reaction equation

HRID 1063228 reaction equation
Cl.C([O:6][C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[S:25][C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[Cl:26])[CH:18]=2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.[CH3:27]O>>[Cl:26][C:23]1[CH:22]=[CH:21][N:20]=[C:19]2[CH:18]=[C:17]([C:15]([N:12]3[CH2:13][CH2:14][N:9]([C:7](=[O:6])[CH3:27])[CH2:10][CH2:11]3)=[O:16])[S:25][C:24]=12

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 69735871HCID 69735871, compound

Product 1

HCID 22278634HCID 22278634, compound

Procedure

HCl (gas) was bubbled through a solution of 4-(7-chloro-thieno[3,2-b]pyridine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (270 mg, 0.71 mmol) in MeOH (5 mL). After 15 min, TLC showed the reaction to be complete. The resulting HCl salt was obtained as a yellow oil (199 mg, 99%) after the solvent was removed under pressure. The title compound was prepared from the resulting HCl salt and acetyl chloride by a procedure analogous to Example 70A. MS: 325 (MH+); HPLC Rf: 3.62; HPLC purity: 95%.

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-ef3c41e23d494318a04a0bac7e5d6ee1
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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