反应详情

A mixture of 20% Pd(OH)2 on carbon (0.5 g) and 1-benzyl-4-cyclopropylamino-3-ethyl-3-methylpiperidine (3.54 g, 13.00 mmol) in methanol (70 ml) was stirred in hydrogen atmosphere (1 atm.) at 60° C. for 48 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-cyclopropylamino-3-ethyl-3-methylpiperidine. Yield 2.3 g (93%), C11H22N2, m/z 183 (M+1).

1. filtrationThe catalyst was filtered off
2. washwashed with methanol and filtrate
3. concentrationwas concentrated to dryness