2-(Ethylamino)ethanol → HCID 9946118, compound

HRID 1063359Notes

Reaction equation

HRID 1063359 reaction equation
Cl.Br[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Cl[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16].[CH2:22]([NH:24][CH2:25][CH2:26][OH:27])[CH3:23]>>[CH2:18]([O:17][C:15]([N:11]1[CH2:12][CH2:13][CH:8]([O:7][CH2:6][CH2:5][CH2:4][CH2:3][N:24]([CH2:22][CH3:23])[CH2:25][CH2:26][OH:27])[CH2:9][CH2:10]1)=[O:16])[CH:19]([CH3:21])[CH3:20]

Participants

4

Reactant 3

HCID 80722-(Ethylamino)ethanolHCID 62365Isobutyl chloroformateHCID 85812949HCID 85812949, compound

Product 1

HCID 9946118HCID 9946118, compound

Procedure

In analogy to example 1.4 and 1.5, reaction of 4-(4-Brom-butoxy)-piperidine hydrogen chloride with isobutyl chloroformate and 2-ethylamino-ethanol yielded 4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butoxy}-piperidine-1-carboxylic acid isobutyl ester, MS: 345 (MH+).

Sources & evidence

ORD record
ord-88ec256c6ca44de989e473469f1b0866
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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