Hydrochloric Acid → HCID 22279489, compound

HRID 1063361Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]Br.[CH3:23][NH:24][CH:25]1[CH2:27][CH2:26]1.[ClH:28]>>[ClH:28].[ClH:28].[CH:25]1([N:24]([CH3:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:27][CH2:26]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 123681,6-Dibromohexane

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

HCID 11029756N-Methylcyclopropanamine

Product 1

HCID 22279489HCID 22279489, compound

Procedure

In analogy to example 1.2a, 1.5 and 1.3, reaction of 4-Hydroxy-piperidine-1-carboxylic-acid tert-butyl ester and 1,6-dibromohexane, N-methylcyclopropylamine followed by treatment with 4N HCl yielded Cyclopropyl-methyl-[6-(piperidin-4-yloxy)-hexyl]-amine dihydrochloride, MS: 255 (MH+).

Sources & evidence

ORD record: ord-7e68591b49f147b5a3e4c61409914040
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964974B2

Reaction notes

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