HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-Piperidin-4-ylprop-2-ynyl methanesulfonate;2,2,2-trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(3-Methanesulfonyloxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86585277 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Piperidin-4-ylprop-2-ynyl methanesulfonate;2,2,2-trifluoroacetic acid | HCID 86585278 | — |
Reaction Steps
A solution of 2.96 g (9.4 mmol) of 4-(3-Methanesulfonyloxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester in 50 ml CH2Cl2 was treated at 0° C. with 25.2 ml of TFA (for 20 min). After 30 min at this temperature, the reaction was evaporated, evaporated again with toluene (4 times) and dried to give 3.6 g (quantitative) of methanesulfonic acid 3-piperidin-4-yl-prop-2-ynyl ester; compound with trifluoro-acetic acid, MS: 218 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964974B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-7e03f128aa5c49228053fc0c3e17dcc5 |
| Source note | uspto-grants-2005_11 |