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HRID1063372

反应详情

EQUATION

反应方程式

HRID 1063372 反应方程式

REACTANTS

反应物

2
Trifluoroacetic acid 分子结构式
HCID6422

Trifluoroacetic acid

C2HF3O2

1,1-Dimethylethyl 4-[3-[(methylsulfonyl)oxy]-1-propyn-1-yl]-1-piperidinecarboxylate 分子结构式
HCID86585277

1,1-Dimethylethyl 4-[3-[(methylsulfonyl)oxy]-1-propyn-1-yl]-1-piperidinecarboxylate

C14H23NO5S

PRODUCTS

产物

1
HCID 86585278 分子结构式
HCID86585278

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
Dichloromethane 分子结构式
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 2.96 g (9.4 mmol) of 4-(3-Methanesulfonyloxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester in 50 ml CH2Cl2 was treated at 0° C. with 25.2 ml of TFA (for 20 min). After 30 min at this temperature, the reaction was evaporated, evaporated again with toluene (4 times) and dried to give 3.6 g (quantitative) of methanesulfonic acid 3-piperidin-4-yl-prop-2-ynyl ester; compound with trifluoro-acetic acid, MS: 218 (MH+).

WORKUP

后处理

  1. customthe reaction was evaporated
  2. customevaporated again with toluene (4 times)
  3. customdried