HCID 69338437, compound → HCID 69338478, compound

HRID 1063441Notes

Reaction equation

HRID 1063441 reaction equation
[NH2:1][CH:2]([OH:23])[C@H:3]([CH3:22])[CH2:4][CH2:5][C:6]1[S:7][C:8]([C:11]#[C:12][CH2:13][CH2:14][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:10]=1>C(O)C.[Pd]>[NH2:1][CH:2]([OH:23])[C@H:3]([CH3:22])[CH2:4][CH2:5][C:6]1[S:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 69338437HCID 69338437, compound

Product 1

HCID 69338478HCID 69338478, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

(2R)-Amino-2-methyl-4-[5-(5-cyclohexylpent-1-ynyl)thiophen-2-yl]butan-1-ol (175 mg, 0.53 mmol) obtained in Example 1 was dissolved in ethanol (9 ml), and 10% palladium-charcoal (90 mg) was added thereto, and then the mixture was stirred under a hydrogen atmosphere for 2 hours. After the palladium-charcoal was filtered out through Celite, the filtrate was evaporated to dryness under reduced pressure to give the title compound (150 mg, 85% yield).

Workup

  1. filtrationAfter the palladium-charcoal was filtered out through Celite
  2. customthe filtrate was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-607b28a754a6430bbfae23c513ae3043
Source dataset
uspto-grants-2005_11
Patent number
US06964976B2

Reaction notes

Loading…