HCID 69338437, compound → HCID 69338478, compound

Participants

Reaction Steps

(2R)-Amino-2-methyl-4-[5-(5-cyclohexylpent-1-ynyl)thiophen-2-yl]butan-1-ol (175 mg, 0.53 mmol) obtained in Example 1 was dissolved in ethanol (9 ml), and 10% palladium-charcoal (90 mg) was added thereto, and then the mixture was stirred under a hydrogen atmosphere for 2 hours. After the palladium-charcoal was filtered out through Celite, the filtrate was evaporated to dryness under reduced pressure to give the title compound (150 mg, 85% yield).

Provenance & Evidence