Sodium ion → 3-[(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methanesulfonyl-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 106351Notes

Reaction equation

HRID 106351 reaction equation
[Br:20][CH2:21][c:22]1[cH:23][c:24]2[n:25][c:26]([Cl:37])[n:27][c:28]([N:31]3[CH2:32][CH2:33][O:34][CH2:35][CH2:36]3)[c:29]2[s:30]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([NH:13][S:14](=[O:15])(=[O:16])[CH3:17])[CH2:11][CH2:12]1.[H-:19].[Na+:18].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([N:13]([S:14](=[O:15])(=[O:16])[CH3:17])[CH2:21][c:22]2[cH:23][c:24]3[n:25][c:26]([Cl:37])[n:27][c:28]([N:31]4[CH2:32][CH2:33][O:34][CH2:35][CH2:36]4)[c:29]3[s:30]2)[CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 166653HydrideHCID 461807264-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholineHCID 67189774tert-Butyl 3-methanesulfonamidopyrrolidine-1-carboxylate

Product 1

HCID 866184073-[(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methanesulfonyl-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-e5371fd6a8564edf9c5e3ea5cda23849
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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