Diethyl phosphonomethanol → 2-Diethylphosphonomethyloxy-5-bromonitrobenzene

HRID 1063612ノート

反応式

HRID 1063612 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[Na].[CH2:13]([O:15][P:16]([CH2:21][OH:22])(=[O:20])[O:17][CH2:18][CH3:19])[CH3:14]>CN(C=O)C>[CH2:13]([O:15][P:16]([CH2:21][O:22][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])([O:17][CH2:18][CH3:19])=[O:20])[CH3:14]

参加物

5

反応物 3

HCID 76513Diethyl phosphonomethanolHCID 27363284-Bromo-1-fluoro-2-nitrobenzeneHCID 5360545Sodium

生成物 1

HCID 539162862-Diethylphosphonomethyloxy-5-bromonitrobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of 2-fluoro-5-bromonitrobenzene (1 mmole) in DMF (5 mL) was cooled to 0° C., and treated with a solution of freshly prepared sodium salt of diethylhydroxymethylphosphonate (1.2 mmole) in DMF (5 mL). The mixture was stirred at room, temperature for 16 h. Evaporation, extraction and chromatography provided 2-diethylphosphonomethyloxy-5-bromonitrobenzene.

後処理

  1. customEvaporation, extraction and chromatography

出典と根拠

ORDレコード
ord-dc59f33fcdf44e22a499b7b5dfadeb9b
出典データセット
uspto-grants-2005_11
特許番号
US06965033B2

反応ノート

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