Hydrochloric Acid → HCID 178484856, compound

Participants

Reaction Steps

1 g (2.71 mmol) of trans-(4-{2-[(3-hydroxy-propyl)-methyl-carbamoyl]-ethoxy}-cyclohexyl)-methyl-carbamic acid tert-butyl ester was dissolved in 5 mL of TBME and 5.4 mL of 5M HCl in TBME were added at 0° C. The solution was stirred at RT, additional 1.5 mL of 5M HCl in TBME were added and stirring was continued. Evaporation of the solvent yielded the crude trans-N-(3-hydroxy-propyl)-N-methyl-3-(4-methylamino-cyclohexyloxy)-propionamide-hydrochloride, MS: 273 (MH+).

Provenance & Evidence