Hydrochloric Acid → HCID 178484856, compound

HRID 1063628Notes

Reaction equation

HRID 1063628 reaction equation
C(O[C:6](=O)[N:7]([C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH2:16][CH2:17][C:18](=[O:25])[N:19]([CH2:21][CH2:22][CH2:23][OH:24])[CH3:20])[CH2:11][CH2:10]1)C)(C)(C)C.[ClH:27]>CC(OC)(C)C>[ClH:27].[OH:24][CH2:23][CH2:22][CH2:21][N:19]([CH3:20])[C:18](=[O:25])[CH2:17][CH2:16][O:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([NH:7][CH3:6])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 178483910HCID 178483910, compound

Product 1

HCID 178484856HCID 178484856, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent3×

Procedure

1 g (2.71 mmol) of trans-(4-{2-[(3-hydroxy-propyl)-methyl-carbamoyl]-ethoxy}-cyclohexyl)-methyl-carbamic acid tert-butyl ester was dissolved in 5 mL of TBME and 5.4 mL of 5M HCl in TBME were added at 0° C. The solution was stirred at RT, additional 1.5 mL of 5M HCl in TBME were added and stirring was continued. Evaporation of the solvent yielded the crude trans-N-(3-hydroxy-propyl)-N-methyl-3-(4-methylamino-cyclohexyloxy)-propionamide-hydrochloride, MS: 273 (MH+).

Workup

  1. stirringstirring
  2. customEvaporation of the solvent

Sources & evidence

ORD record
ord-1bb6dc9a7d9f4223947450353822daa8
Source dataset
uspto-grants-2005_11
Patent number
US06965048B2

Reaction notes

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