2-Chloro-5-(chloromethyl)pyridine → {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid

HRID 1063673Notes

Reaction equation

HRID 1063673 reaction equation
ClC1C=CC(CCl)=CN=1.COC(=O)COC1C=C(OC)C(S)=CC=1C.C[O:27][C:28](=[O:58])[CH2:29][O:30][C:31]1[CH:36]=[C:35]([O:37][CH3:38])[C:34]([S:39][CH2:40][C:41]2[CH:42]=[N:43][C:44]([C:47]3[CH:52]=[CH:51][C:50]([C:53]([F:56])([F:55])[F:54])=[CH:49][CH:48]=3)=[CH:45][CH:46]=2)=[CH:33][C:32]=1[CH3:57]>>[CH3:38][O:37][C:35]1[C:34]([S:39][CH2:40][C:41]2[CH:42]=[N:43][C:44]([C:47]3[CH:48]=[CH:49][C:50]([C:53]([F:56])([F:55])[F:54])=[CH:51][CH:52]=3)=[CH:45][CH:46]=2)=[CH:33][C:32]([CH3:57])=[C:31]([CH:36]=1)[O:30][CH2:29][C:28]([OH:58])=[O:27]

Participants

4

Reactant 3

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 11311052(4-Mercapto-5-methoxy-2-methyl-phenoxy)-acetic Acid Methyl EsterHCID 20827059{5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester2×

Product 1

HCID 10173937{5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid

Procedure

The title compound was prepared from 2-Chloro-5-chloromethyl-pyridine and 1D in a manner analogous to Example 1F. MS m/z 370 (M+2). Step 2. Preparation of {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester (Compound 19B)

Sources & evidence

ORD record
ord-eafb46104020444ea3e18ae55255d0ec
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

Loading…