HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-(chloromethyl)pyridine → {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-(chloromethyl)pyridine | HCID 155479 | — |
| Reactant | (4-Mercapto-5-methoxy-2-methyl-phenoxy)-acetic Acid Methyl Ester | HCID 11311052 | — |
| Reactant | {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester | HCID 20827059 | — |
| Product | {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid | HCID 10173937 | — |
Reaction Steps
The title compound was prepared from 2-Chloro-5-chloromethyl-pyridine and 1D in a manner analogous to Example 1F. MS m/z 370 (M+2). Step 2. Preparation of {5-Methoxy-2-methyl-4-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester (Compound 19B)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964983B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-eafb46104020444ea3e18ae55255d0ec |
| Source note | uspto-grants-2005_11 |