(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester → {7-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-indan-4-yloxy}-acetic acid

HRID 1063698Notes

Reaction equation

HRID 1063698 reaction equation
Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[O:5][N:4]=1.C[O:19][C:20](=[O:33])[CH2:21][O:22][C:23]1[CH:31]=[CH:30][C:29]([SH:32])=[C:28]2[C:24]=1[CH2:25][CH2:26][CH2:27]2>>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][S:32][C:29]3[CH:30]=[CH:31][C:23]([O:22][CH2:21][C:20]([OH:33])=[O:19])=[C:24]4[C:28]=3[CH2:27][CH2:26][CH2:25]4)[CH:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl EsterHCID 220642603-(Chloromethyl)-5-[4-(trifluoromethyl)phenyl]isoxazole

Product 1

HCID 22280211{7-[5-(4-Trifluoromethyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-indan-4-yloxy}-acetic acid

Procedure

The title compound was prepared in a manner analogous to Example 1F using 42C and 12C. MS m/z 464 (M+1).

Sources & evidence

ORD record
ord-65fed0704b3342b68c04984bb64a1f7c
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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