(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester → {7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

HRID 1063705Notes

Reaction equation

HRID 1063705 reaction equation
C[O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.Cl[CH2:18][C:19]1[CH:20]=[C:21]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][N:26]=2)[CH:22]=[CH:23][CH:24]=1>>[F:34][C:31]([F:32])([F:33])[C:28]1[CH:29]=[CH:30][C:25]([C:21]2[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=2)[CH2:18][S:15][C:12]2[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:16])=[C:7]3[C:11]=2[CH2:10][CH2:9][CH2:8]3)=[N:26][CH:27]=1

Participants

3

Reactant 2

HCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl EsterHCID 222801602-(3-Chloromethyl-phenyl)-5-trifluoromethyl-pyridine

Product 1

HCID 22280108{7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 12C and 53B. MS m/z 474 (M+1).

Sources & evidence

ORD record
ord-1a6a325aa2954912bdc5c73dc1d51d44
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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