Potassium Bromide → HCID 22280073, compound

HRID 1063710Notes

Reaction equation

C[O:2][C:3](=[O:34])[CH2:4][O:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[CH:17][CH:16]=2)=[CH:8][C:7]=1[CH3:33].[K+].[Br-]>>[Cl:12][C:10]1[C:9]([S:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:30])([F:31])[F:32])=[CH:27][CH:28]=3)=[CH:19][CH:20]=2)=[CH:8][C:7]([CH3:33])=[C:6]([CH:11]=1)[O:5][CH2:4][C:3]([OH:34])=[O:2]

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 20827037HCID 20827037, compound

Product 1

HCID 22280073HCID 22280073, compound

Procedure

The title compound was prepared in the manner analogous to Example 1 using 61A. mp 142-143° C.; IR (KBr) cm−1: 3074, 1747, 1321, 1234, 1175, 1124; 400 MHz 1H NMR (DMSO-d6): δ 13.01 (br(s), 1H), 7.67-7.73 (m, 2H), 7.57-7.64 (m, 2H), 7.16-7.25 (m, 4H), 6.87-6.95 (m, 4H), 5.15 (s, 2H), 4.69 (s, 2H), 4.07 (s, 2H), 2.07 (s, 3H); MS m/z 495 (M−1). Anal. Calc'd for C24H20ClF3O4S: C, 58.01; H, 4.06. found: C, 57.73; H, 4.06.

Sources & evidence

ORD record: ord-7d11d4de01964d3dbb0e53a6d6e4645a
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964983B2

Reaction notes

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