4-Hydroxybenzyl Alcohol → {7-[4-(2,4-Difluoro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid

HRID 1063716Notes

Reaction equation

HRID 1063716 reaction equation
C[O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.ClCC1(F)C=CC(OCC2C=CC=CC=2)=C(F)C1.O[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=1.Br[CH2:45][C:46]1[CH:51]=[CH:50][C:49]([F:52])=[CH:48][C:47]=1[F:53].ClCC1(C(F)(F)F)C=CC(OCC2C=CC=CC=2)=CC1>>[F:53][C:47]1[CH:48]=[C:49]([F:52])[CH:50]=[CH:51][C:46]=1[CH2:45][O:43][C:40]1[CH:41]=[CH:42][C:37]([CH2:36][S:15][C:12]2[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:16])=[C:7]3[C:11]=2[CH2:10][CH2:9][CH2:8]3)=[CH:38][CH:39]=1

Participants

6

Reactant 5

HCID 1254-Hydroxybenzyl AlcoholHCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl EsterHCID 694703524-Chloromethyl-(2,4-difluoro-benzyloxy-benzene)HCID 694705984-Chloromethyl-(4-trifluoromethyl-benzyloxy-benzene)

Product 1

HCID 22280069{7-[4-(2,4-Difluoro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 12C and 4-chloromethyl-(2,4-difluoro-benzyloxy-benzene) prepared from 4-hydroxymethyl-phenol and 1-bromomethyl-2,4-difluoro-benzene in the manner analagous to Examples 14A and 14B. MS m/z 471 (M+1).

Sources & evidence

ORD record
ord-5202209c1b934b9aa7fc8065f84f2aa0
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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