HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzyl Alcohol → {7-[4-(2,4-Difluoro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzyl Alcohol | HCID 125 | — |
| Reactant | 1-(Bromomethyl)-2,4-difluorobenzene | HCID 90297 | — |
| Reactant | (7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester | HCID 20770872 | — |
| Reactant | 4-Chloromethyl-(2,4-difluoro-benzyloxy-benzene) | HCID 69470352 | — |
| Reactant | 4-Chloromethyl-(4-trifluoromethyl-benzyloxy-benzene) | HCID 69470598 | — |
| Product | {7-[4-(2,4-Difluoro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid | HCID 22280069 | — |
Reaction Steps
The title compound was prepared in the manner analogous to Example 1F using 12C and 4-chloromethyl-(2,4-difluoro-benzyloxy-benzene) prepared from 4-hydroxymethyl-phenol and 1-bromomethyl-2,4-difluoro-benzene in the manner analagous to Examples 14A and 14B. MS m/z 471 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964983B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-5202209c1b934b9aa7fc8065f84f2aa0 |
| Source note | uspto-grants-2005_11 |