(8-Mercapto-chroman-5-yloxy)-acetic acid methyl ester → {8-[4-(2,5-Dichloro-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic Acid

HRID 1063748Notes

Reaction equation

HRID 1063748 reaction equation
C[O:2][C:3](=[O:17])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([SH:16])=[C:12]2[C:7]=1[CH2:8][CH2:9][CH2:10][O:11]2.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[CH2:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34]Cl)=[CH:30][CH:29]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[CH2:26][O:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:34][S:16][C:13]2[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:17])=[C:7]3[C:12]=2[O:11][CH2:10][CH2:9][CH2:8]3)=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 11288267(8-Mercapto-chroman-5-yloxy)-acetic acid methyl esterHCID 222800501,4-Dichloro-2-(4-chloromethyl-phenoxymethyl)-benzene

Product 1

HCID 22280019{8-[4-(2,5-Dichloro-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic Acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using (8-mercapto-chroman-5-yloxy)-acetic acid methyl ester and 1,4-Dichloro-2-(4-chloromethyl-phenoxymethyl)-benzene prepared in the manner analagous to Example 71A. m/z 519 (M+1).

Workup

  1. customprepared in the manner analagous to Example 71A

Sources & evidence

ORD record
ord-a4649d73aaf44738a61f179c5e77a7bb
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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