(8-Mercapto-chroman-5-yloxy)-acetic acid methyl ester → {8-[4-(5-Trifluoromethyl-pyridine-2-yl)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid

HRID 1063750Notes

Reaction equation

HRID 1063750 reaction equation
C[O:2][C:3](=[O:17])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([SH:16])=[C:12]2[C:7]=1[CH2:8][CH2:9][CH2:10][O:11]2.Cl[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=2)=[CH:22][CH:21]=1>>[F:35][C:32]([F:33])([F:34])[C:29]1[CH:30]=[CH:31][C:26]([C:23]2[CH:24]=[CH:25][C:20]([CH2:19][S:16][C:13]3[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:17])=[C:7]4[C:12]=3[O:11][CH2:10][CH2:9][CH2:8]4)=[CH:21][CH:22]=2)=[N:27][CH:28]=1

Participants

3

Reactant 2

HCID 11288267(8-Mercapto-chroman-5-yloxy)-acetic acid methyl esterHCID 222800672-[4-(Chloromethyl)phenyl]-5-(trifluoromethyl)pyridine

Product 1

HCID 22280072{8-[4-(5-Trifluoromethyl-pyridine-2-yl)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using (8-mercapto-chroman-5-yloxy)-acetic acid methyl ester and 18B. MS m/z 490 (M+1).

Sources & evidence

ORD record
ord-7eb24203aaee4f208245831a6cecc0cc
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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