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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1063750Generated: November 1, 2026

(8-Mercapto-chroman-5-yloxy)-acetic acid methyl ester → {8-[4-(5-Trifluoromethyl-pyridine-2-yl)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid

https://huagongshe.com/reaction/1063750

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(8-Mercapto-chroman-5-yloxy)-acetic acid methyl esterHCID 11288267—
Reactant2-[4-(Chloromethyl)phenyl]-5-(trifluoromethyl)pyridineHCID 22280067—
Product{8-[4-(5-Trifluoromethyl-pyridine-2-yl)-benzylsulfanyl]-chroman-5-yloxy}-acetic acidHCID 22280072—

Reaction Steps

The title compound was prepared in the manner analogous to Example 1F using (8-mercapto-chroman-5-yloxy)-acetic acid methyl ester and 18B. MS m/z 490 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06964983B2
Source datasetuspto-grants-2005_11
ORD IDord-7eb24203aaee4f208245831a6cecc0cc
Source noteuspto-grants-2005_11