Potassium Bromide → HCID 22280010, compound

HRID 1063755Notes

Reaction equation

C[O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15][CH2:16][C:17]2[C:18]([C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])=[N:19][O:20][C:21]=2[CH3:22])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.[K+].[Br-]>>[Cl:29][C:28]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:30])[C:23]=1[C:18]1[C:17]([CH2:16][S:15][C:12]2[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:31])=[O:2])=[C:7]3[C:11]=2[CH2:10][CH2:9][CH2:8]3)=[C:21]([CH3:22])[O:20][N:19]=1

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 20827071HCID 20827071, compound

Product 1

HCID 22280010HCID 22280010, compound

Procedure

The title compound was prepared in the manner analogous to Example 1 using 88A. mp 151-152° C.; IR (KBr) cm−1: 3084, 1743, 1430, 1277, 1245, 1106; 400 MHz 1H NMR (DMSO-d6): δ 12.97 (br(s), 1H), 7.47-7.70 (m, 3H), 6.90 (d, 1H, J=8.5 Hz), 6.52 (d, 1H, J=8.5 Hz), 4.63 (s, 2H), 3.58 (s, 2H), 2.75 (t, 2H, J=7.6 Hz), 2.65 (t, 2H, J=7.6 Hz), 2.07 (s, 3H), 1.89 (pentet, 2H) MS m/z 464 (M+1). Anal. Calc'd for C22H19Cl2NO4S: C, 56.90; H, 4.12; N, 3.02. found: C, 56.51; H, 3.96; N, 2.95.

Sources & evidence

ORD record: ord-d07f946bb63d4d0eb7dc648225249aec
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964983B2

Reaction notes

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