3-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazole → {8-[5-(4-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-5-yloxy}-acetic Acid

HRID 1063759Notes

Reaction equation

HRID 1063759 reaction equation
Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[O:5][N:4]=1.C[O:16][C:17](=[O:31])[CH2:18][O:19][C:20]1[CH:29]=[CH:28][C:27]([SH:30])=[C:26]2[C:21]=1[CH2:22][CH2:23][CH2:24][O:25]2>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][S:30][C:27]3[CH:28]=[CH:29][C:20]([O:19][CH2:18][C:17]([OH:31])=[O:16])=[C:21]4[C:26]=3[O:25][CH2:24][CH2:23][CH2:22]4)[CH:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 14811003-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazoleHCID 11288267(8-Mercapto-chroman-5-yloxy)-acetic acid methyl ester

Product 1

HCID 22280159{8-[5-(4-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-chroman-5-yloxy}-acetic Acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 3-chloromethyl-5-(4-chloro-phenyl)-isoxazole and (8-mercapto-chroman-5-yloxy)-acetic acid methyl ester. mp 131-133° C.; MS m/z 446 (M+1).

Sources & evidence

ORD record
ord-7a4a1e6f0a2841d2aebe2015dcf7b381
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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