反应详情

温度

10 °C

A three-necked flask was charged with p-Anisidine (50 g), Et3N (40.43 g) and methyl ethyl ketone (100 ml). The resulting slurry was cooled to 10° C. and 3-chloropropionyl chloride (50.74 g) was slowly added. The temperature was allowed to rise to 60° C. during the addition. The mixture was then refluxed for 1 hour and cooled to 50° C. The solids were collected by filtration, washed with water, and dried at 50° C. to constant weight to give N-(4-methoxyphenyl)-3-chloropropionamide (56.42 g, 86.8%).

1. additionto rise to 60° C. during the addition
2. temperatureThe mixture was then refluxed for 1 hour
3. temperaturecooled to 50° C
4. filtrationThe solids were collected by filtration
5. washwashed with water
6. customdried at 50° C. to constant weight