3-Bromo-4-fluorophenyl acetate → 3-Bromo-4-Fluorophenol

HRID 1063845Notes

Reaction equation

HRID 1063845 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([Br:12])[CH:6]=1)(=O)C>C(N(C(C)C)CC)(C)C.CO>[Br:12][C:7]1[CH:6]=[C:5]([OH:4])[CH:10]=[CH:9][C:8]=1[F:11]

Participants

4

Reactant 1

HCID 207854593-Bromo-4-fluorophenyl acetate

Product 1

HCID 27833813-Bromo-4-Fluorophenol

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 81531DiisopropylethylamineSolvent

Procedure

A solution of 0.80 gm (3.43 mMol) O-acetyl 3-bromo-4-fluorophenol in 10 mL 6% diisopropylethylamine in methanol was stirred at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure at 0° C. to provide the desired compound.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure at 0° C.

Sources & evidence

ORD record
ord-69890c9469264d2d88d8f68be8d8c0b7
Source dataset
uspto-grants-2005_11
Patent number
US06967201B1

Reaction notes

Loading…