Sulfuric Acid → HCID 22144695, compound

HRID 1063847Notes

Reaction equation

HRID 1063847 reaction equation
[CH2:1]([C:4]1[C:9]([Br:10])=[C:8]([F:11])[CH:7]=[CH:6][C:5]=1[OH:12])[CH:2]=C.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[Br:10][C:9]1[C:4]2[CH:1]=[CH:2][O:12][C:5]=2[CH:6]=[CH:7][C:8]=1[F:11]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22144926HCID 22144926, compound

Product 1

HCID 22144695HCID 22144695, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Beginning with 3 gm (13 mMol) 2-allyl-3-bromo-4-fluorophenol, the title compound was prepared in 98% yield essentially by the procedure described in Preparation XXVII with the exception that the cyclization/dehydration step was performed using sulfuric acid in toluene.

Sources & evidence

ORD record
ord-c71d8776648843fb9ebf87ebfc6dd851
Source dataset
uspto-grants-2005_11
Patent number
US06967201B1

Reaction notes

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