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A mixture of 5.82 gm (14.8 mMol) N-benzyl-N-[N′-tert-butoxycarbonyl-(S)-valinyl]glycine ethyl ester in 20 mL 4N hydrogen chloride in dioxane was stirred at room temperature under a nitrogen atmosphere over night. The reaction mixture was concentrated under reduced pressure and the residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The aqueous phase was extracted again with dichloromethane. The combined organic phases were dried over magnesium sulfate and concentrated under reduced pressure to provide 4.2 gm (97%) of the desired compound as a yellow oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate
3. extractionThe aqueous phase was extracted again with dichloromethane
4. dry with materialThe combined organic phases were dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure