Pyridine → HCID 23402343, compound

HRID 1063852Notes

Reaction equation

HRID 1063852 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:7](=[O:13])[C@H:8]([CH:10]([CH3:12])[CH3:11])[NH2:9])C.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:14]([N:6]1[CH2:5][C:4](=[O:3])[NH:9][C@@H:8]([CH:10]([CH3:12])[CH3:11])[C:7]1=[O:13])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 23402348N-benzyl-N-[(S)-valinyl]glycine Ethyl Ester

Product 1

HCID 23402343HCID 23402343, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4.2 gm (14.4 Mol) N-benzyl-N-[(S)-valinyl]glycine ethyl ester and 1.2 mL (0.98 mMol) pyridine in 85 mL toluene was heated at reflux for 3 hours. The reaction mixture was then concentrated under reduced pressure to provide 3.4 gm (96%) of the desired compound as an oily solid.

Workup

  1. temperatureat reflux for 3 hours
  2. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-9656edbda238490089920d8b71cb61c9
Source dataset
uspto-grants-2005_11
Patent number
US06967201B1

Reaction notes

Loading…