Hydrochloric Acid → HCID 22277046, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 2-[4-tert-butoxycarbonyl-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate (4.7 g) in ethyl acetate (40 ml) was added dropwise a solution 4N-hydrogen chloride in ethyl acetate (40 ml) under ice-cooling. After being stirred at 0° C. for 30 minutes and at ambient temperature for 1 hour, reaction mixture was concentrated in vacuo and hydrogen chloride was azeotropically removed with toluene to give tert-butyl 2-[7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate hydrochloride (4.2 g) as an oil.

Provenance & Evidence