Hydrochloric Acid → HCID 22277046, compound

HRID 1063893Notes

Reaction equation

HRID 1063893 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]([CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])([C:15]2[S:16][C:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]4[O:30][CH:29]=[N:28][CH:27]=4)=[CH:22][CH:21]=3)=[CH:18][CH:19]=2)[S:11](=[O:40])(=[O:39])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:41]>C(OCC)(=O)C>[ClH:41].[O:30]1[C:26]([C:23]2[CH:22]=[CH:21][C:20]([C:17]3[S:16][C:15]([C:12]4([CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[S:11](=[O:40])(=[O:39])[CH2:10][CH2:9][NH:8][CH2:14][CH2:13]4)=[CH:19][CH:18]=3)=[CH:25][CH:24]=2)=[CH:27][N:28]=[CH:29]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22276535HCID 22276535, compound

Product 1

HCID 22277046HCID 22277046, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of tert-butyl 2-[4-tert-butoxycarbonyl-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate (4.7 g) in ethyl acetate (40 ml) was added dropwise a solution 4N-hydrogen chloride in ethyl acetate (40 ml) under ice-cooling. After being stirred at 0° C. for 30 minutes and at ambient temperature for 1 hour, reaction mixture was concentrated in vacuo and hydrogen chloride was azeotropically removed with toluene to give tert-butyl 2-[7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate hydrochloride (4.2 g) as an oil.

Workup

  1. temperaturecooling
  2. customreaction mixture
  3. concentrationwas concentrated in vacuo and hydrogen chloride
  4. customwas azeotropically removed with toluene

Sources & evidence

ORD record
ord-4ed15cd16ad448fca8a63f2867d235b3
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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